The easiest way to enter the Net Income for the spouse on the Info page (and put their province of Residence as Non-Resident) If you enter it sufficiently high to eliminate the credit that takes it out of everywhere without creating overrides that interfere with e-filing.
If you want to override the Spousal Credit on Schedule 1 and the Provincial Tax Schedule (ex BC428) to zero instead, you will have to change your settings to ignore overrides when attempting to efile or Profile will give you warnings and not allow you to e-file it with the overrides. Some settings will allow you to efile the override if you tick with the Review or Partner Review. It is not CRA preventing you from e-filing with that information, it is Profile's setting in order to prevent you from filing with "accidental" overrides.
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